On Sunday, the powerful Argentine with the massive forehand that zips along at more than 100 miles per hour will face two-time US Open champion Novak Djokovic, who defeated Kei Nishikori 6-3, 6-4, 6-2 in the second semifinal Friday night.
After Del Potro made it past an injured Rafael Nadal, who retired when trailing by two sets on Friday, Djokovic looked superb as he romped past Kei Nishikori to reach his eighth final at Flushing Meadows.
The 32-year-old won his 17th Grand Slam title at the French Open in June and has only lost four matches all year so far with two of those defeats coming through an injury enforced retirement.
He has resurrected his career impressively after minor surgery on his long-term elbow injury, which kept him out of the game for six months past year.
Nadal, the world's No. 1 player and the defending champion in NY, retired against Juan Martin del Potro, trailing 7-6 (7-3), 6-2 about two hours into the first semifinal of the day in Flushing Meadows.
Del Potro led a standing ovation on Arthur Ashe Stadium when Nadal walked gingerly off court.
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It was the ninth consecutive slam semi-final that the 31-year-old has won and sends him through to a 23rd final.
The effort took its toll, with the Spaniard twice needing to have his right knee bandaged before calling it a day after the conclusion of the second set.
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I give it my all for United always. "You struggle along with us when we lose and celebrate with us when we win, just like yesterday".
"He fights every match from the first to the last point".
"But we've played 18 times against each other".
"I don't know what can happen in a couple of days or a couple of weeks". "I don't like to see him suffering on court today". It was so hard for me to keep playing, I was in too much pain. "I hate to retire, but staying one more set out there, playing like this, would be too much for me". "The problem is this time was something little bit more aggressive because was in one movement".
Nishikori - the first Japanese man to reach a US Open semifinal in the Open era - was a finalist in NY in 2014.
"That's frustrating. Can't tell you another thing".
His victory over Dominic Thiem reminded him of Wimbledon, where he outlasted Juan Martin del Potro in five sets in the quarterfinals before Novak Djokovic edged him in a 10-8 fifth set in the next round.
Del Potro's game couldn't be much more different and Djokovic will have to come up with the answers to the huge firepower at the Argentine's disposal. "Last year was a fantastic year".
The Japanese player's spirit was finally broken and his serve followed, with Djokovic claiming his fourth break with a fist-pumping celebration before serving for the match. "I'm going to keep fighting and working hard to keep enjoying this tour and keep having chances to compete at the highest level". "All my career everybody said that because of my style, I will have a short career", he noted.
"I waited as much as I can".