If no senators change their votes from Friday's cloture roll call, the final tally will sit at 50-48 at Saturday's final confirmation vote, enough for Republicans to confirm Kavanaugh to the Supreme Court with no senator holding the sole deciding vote. Jeff Flake, another conservative swing vote, said Friday that he would vote to confirm Kavanaugh.
The senate is expected to confirm Kavanaugh to the Supreme Court on Saturday around 9pm United Kingdom time.
Joe Manchin was the only Democrat Senator to vote in favour of Kavanaugh's confirmation.
A sharply partisan battle over Kavanaugh became an intense political drama when university professor Christine Blasey Ford accused Kavanaugh of sexual assault when they were in high school in Maryland in 1982. Kavanaugh's nomination has been slowed by an allegation of sexual assault and accusations of sexually inappropriate behavior, allegations he has vehemently denied.
All but one Republican lined up behind him, arguing that a truncated FBI investigation turned up no corroborating witnesses and that Kavanaugh had sterling credentials for the court.
The FBI submitted its investigation early this week, which was then sent to the Senate for the lawmakers to have a look at it and have an informed decision.
Collins, meanwhile, is expected to announce her decision on Kavanaugh in a 3 p.m. floor vote.
Theresa May Throws Shapes To 'Dancing Queen' At Tory Conference
Referring to her viral dance moves during her Africa tour, the UK PM awkwardly pumped her arms in the air and made similar moves. Her speech was aimed at providing an upbeat vision for Britain post-Brexit - and after eight years of austerity.
"Judge Kavanaugh has received rave reviews for his 12-year track record as a judge, including for his judicial temperament", she said.
"We must always remember that it is when passions are most inflamed that fairness is most in jeopardy", said Collins, perhaps the chamber's most moderate Republican.
In the procedural vote Friday that handed Republicans their crucial initial victory, senators voted 51-49 to limit debate, defeating Democratic efforts to scuttle the nomination with endless delays.
Vice President Mike Pence planned to be available on Saturday in case his tie-breaking vote was needed. Kavanaugh, who now sits on the D.C. Circuit Court of Appeals and previously worked for the independent counsel's office during the investigation of President Bill Clinton, described opposition to his nomination as "revenge on behalf of the Clintons".
Senate Republicans, except for Lisa Murkowski, have stood by him in a move that could resonate, particularly with women voters, in the November 6 elections to determine control of the Senate and House of Representatives.
Murkowski waits to board the Senate subway auto as she heads to her office after listening to Collins declare she would vote to confirm Kavanaugh's nomination. Saturday's roll call seemed destined to be almost party-line, with just a single defector from each side capping a contest fought against the backdrop of the #MeToo movement and President Donald Trump's unyielding support of his nominee.
Hours before Senators are set to vote, protesters took to Capital Hill to urge them to vote against Brett Kavanaugh's confirmation.
Murkowski said after last week's hearings before the Judiciary Committee that she felt strongly that "the appearance of impropriety was unavoidable". They said he also seemed too ready to rule for Trump in a possible federal court case against the president.
"If my good friend Steve Daines can participate in his daughter's wedding and ensure Judge Kavanaugh is confirmed to the Supreme Court, I'm happy to help for the sake of family and country", Gianforte said in a statement.