Egyptian tour guides hold a candlelight vigil at the base of the Great Pyramid of Giza in solidarity with victims of attacks in Paris and Beirut and the Russian plane crash in northern Sinai, on the outskirts of Cairo, Egypt, Nov. 15, 2015.
The blast took place in Giza around 6:15pm local time on Friday, Egypt's interior ministry said in a statement.
The bus hit the device after it went off its planned route without alerting security forces, Mr Madbouly added.
The deceased were part of a group of 14 tourists who were being shown around by an Egyptian and a driver, both of whom were injured.
"The DFA today advised Filipinos planning to travel to Egypt to exercise a higher level of vigilance when visiting tourist destinations there", the agency said in a statement.
ED GILES GETTY IMAGESEgypt's tourism industry is showing encouraging signs of recovery after years in the doldrums
The white tourist bus could be seen with its windows shattered and surrounded by soot-covered debris.
The bombing is the first deadly attack against foreign tourists in Egypt for over a year and comes as the tourism sector, a vital source of foreign currency revenue, recovers from a sharp drop in visitor numbers since the country's 2011 uprising. "It was awful, people screaming", she told Reuters, speaking at al-Haram hospital, where the injured were taken.
Prosecutors said they had launched an investigation "to arrest the perpetrators".
Prime Minister Mostafa Madbouli visited the injured tourists in hospital, where he announced that the tour guide had died from his wounds. But Daesh terrorists have a history of targeting tourists.
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McCaffrey also had little time for what he called the president's boasts about how fraught with danger visiting Iraq could be. Trump's visit to Iraq came a day after he held a video conference from the Oval Office with military members around the globe.